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Archive for February, 2008

News - Washington diary: Body shock

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By sheer coincidence my medical issues started as soon as I landed in the US four years ago.

Only 48 hours after getting off the plane in Washington I was seized by numbing pain in my upper jaw and rushed to a smart dental clinic near the White House.

I pointed to a throbbing molar and was puzzled to find the unusually monosyllabic nurse taking an X-ray of every single tooth in my mouth with quiet and unflinching determination.

She returned half an hour later with the maestro of the clinic who pinned 36 or so stamp sized X-rays on a back-lit board as if they were part of an avant-garde art project and then gave a PowerPoint presentation entitled something like “My vision for your mouth”.

“What about the tooth that hurts?” I asked innocently.

“Thas juss the beginning,” said Dr Harrison, a southern gent with a pencil-thin moustache arching over a blindingly white smile.

“We are gonna work together for three years to get everything in perfect order! An I promise, I won’t have to see ya more than once a month.”


The health industry had officially declared me fair game, easy prey

When the doctor had exited in a swoosh of fluttering white to “work with” the next patient, the nurse leant over as if in deep confidence and added: “You are SOOO lucky to be working with Dr Harrison! He is the beeeast!”, making “best” sound like “beast”.

I never returned after my root canal operation. I chose to become a dental fugitive, hounded every six weeks by increasingly urgent letters reminding me of the doctor’s vision and my empty promises. I am certain that my mouth is on a blacklist somewhere.

Flatulent joints

Two months later the next chapter of bodily woes was opened. One day, out of the blue, without warning and for no apparent reason, my neck felt as if I had survived a garrotting.

I ventured into the hitherto unknown world of chiropractors.

Surgeon holds a scalpel

You can run but you can’t hide from the surgeon’s knife

Dr Drug dysfunction erectile
X-rayed everything above my shoulders and explained to me that - among other things - I had too much gas in my joints, which is why I would soon hear a flatulent noise as he took my neck into a half nelson.

As I contemplated the notion of farting joints, the chiropractor’s fleshy hands fastened around my head, yanking it left and then right as if I was an extra in some martial arts movie. I heard the advertised noise and felt instantly better as the pain seeped away.

“Thank you, Dr Schweinstein,” I said with genuine relief and admiration for the healing profession. “That will be it then?” I added for good measure, heading for the door.

The doctor fixed me with watery blue eyes.

“Actually,” he intoned with a flat, yet authoritative voice, “this is just the prologue, you might say. What I have in mind for you is a two-year programme… a standard course of chiro-therapy to get your neck back in shape. The good news is: shouldn’t need you here more than once a week! Your insurance should cover some, if not most of it.”

The cost of this healing process to the uninsured would have been $150 a week. I wondered how the estimated 50m Americans who have no private medical insurance cope. They don’t, of course.

But they weren’t on my mind at this stage. I was planning another getaway. A fugitive from medicine… twice over.

Midlife crisis

Four months later I was reading the New York Times and my then seven-year-old son asked me: “Dad, why are you holding the newspaper like that?”

“Like what?”

“Like that… so far!” he said and stretched his little arms straight out.

Man has his eyesight tested

Perfect vision - just in one’s dreams

I hadn’t even noticed how my reading arm had got longer and longer.

So my eyes were next. At least the optician was a “walk-in”.
No appointments, no waiting room, no dog-eared copies of last month’s Time Magazine and Yachting Monthly.

The verdict: long sighted.

“Why?” I asked the optician, whose name escapes me. “I have always had perfect vision!”

His nose crinkled and I knew I should have kept my mouth shut. No optician believes in perfect vision. It’s presumptuous and it’s not good for business.

“How old are you?” he asked.

“Forty-one,” I replied.

“Ahhhhh,” he said in a voice oozing pity, understanding and wisdom all coated in glee. “It’s the age.”

And with those three words my midlife crisis started.

The healthcare industry had officially declared me fair game, easy prey, a rich seam of never-ending profits.


I had hit rock bottom. What could be next?

I left the opticians and stumbled, diminished, into the glare of a Washington summer’s day.

I walked down the road fingering my new glasses - frames so sleek, lenses so petite they were almost invisible - almost - when I felt my Blackberry buzz to life in my trouser pocket.

I put on my new specs clumsily, half enjoying this pompous new prop, and allowed them to slide professorially to the tip of my nose. I glanced down at the tiny screen. It was a joy to see so clearly.

An e-mail flashed up from someone called Kevin. I assumed it was work and clicked to open.

“Need Viagra, Cialis, Levitra?” Kevin asked. “We can help! You can perform!” It wasn’t the Kevin I thought it was.

Metatarsal hell

I had hit rock-bottom. What could possibly be next? A few months later I got the answer: my feet.

I have always had feet so wide they defied even the most comfy Hush Puppies. To me, Birkenstocks felt like winkle-pickers.

Victoria Beckham sits in the crowd watching the English football team play

Fellow bunion sufferer Victoria Beckham opts for sensible boots

The pain was beginning to make me hobble and I was about to learn a new word: podiatry.

My podiatrist, a tower of a man who wears disconcertingly orange clogs with his blue surgical jump suit, eased me into the wonderful world of podiatry.

“No surgery, yet, Matt. Foot surgery is a serious business… we’ll give you some orthotics first.”

These specially moulded soles were the most expensive shoes I have ever bought and they didn’t work. Six months later the pain was so bad that I had to go under the knife.

I would like to say that I have joined the hallowed order of the broken metatarsal, just in time for the World Cup.

Rooney, Beckham, Owen, Frei… even if I was nursing MY metatarsal on the sofa watching them test theirs on the pitch. But uk tadalafil
I shared my pain with the other Beckham, not David, Victoria.

And it wasn’t the metatarsal per se… it was alternative tadalafil
. I am talking about an excrescence of the bone resulting in a serious realignment of the toes. I am talking about a… bunion.

Posh Spice has one, a whopper that sticks out of her golden lace thong sandals like a raw pink golf ball. And I have two. One on each foot.

Hobbling hordes

“Bunion?” Isn’t that what women get for wearing the wrong shoes?” a friend asked. True.

About 50% of American women get bunions, a statistic that didn’t make me feel any better. I owe mine to my mother. Yes, they are hereditary and no, I have never worn stilettos.

“Bunion?” I asked the doctor. “Is there no fancier word? Something in Latin perhaps. Something complicated, more interesting?”

“Well, bunion is the ancient Greek word for turnip. Does that help?” the doctor with the orange clogs asked. (*)

No, it didn’t.

The worst thing is that the surgery necessary to remove a “turnip” is long, complicated, painful and could end in failure.

It involves hobbling around for eight weeks with a surgical boot that could have been invented by a workshop of medieval torturers on attachment to the Ministry of Funny Walks.

I hit my low point last week. I was waiting in the surgery for my post operation check-up.

I was surrounded by middle-aged women wearing the same boot. My fellow patients. The hobbling regiment of hop-alongs.

A lady with a magenta rinse turned to me and said: “Honey, I feel so sorry for you. You are the wrong age and the wrong gender to have a bunionectomy!”

She recommended I check out an internet talk show called Life Beyond Bunions. I didn’t know whether to feel flattered or flattened.


*bunion: medical condition known as hallux valgus. Origin early 18th century, unknown origin, perhaps Old French buignon, from buigne, bump on the head (Oxford English Dictionary)


Send us your comments on this week’s Washington Diary

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News - 555 posts may go in plant closure

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A pharmaceutical company has announced plans to close its plant in Hampshire with the loss of 555 posts.


The Eli Lilly site in Basingstoke has 445 employees and 111 tadalafil soft
.


Eli Lilly said about 100 people could be eligible for early retirement, some will be offered redeployment but about 300 workers will be made redundant.


The company said the closure is subject to consultation with employees. Andrew Hotchkiss, managing director, said the cuts were caused by “over-capacity”.


Proposing this site closure has been extremely difficult
Andrew Hotchkiss
managing director


The firm currently cialis drug prescription
medicines which include Zyprexa, a treatment for severe mental illness and Cialis, a treatment for erectile dysfunction.


The company said the closure plans would not have any impact on patients using the medicines.


Mr Hotchkiss said: “Proposing this site closure has been extremely difficult as we are reluctant to lose the highly-skilled, potenzmittel tadalafil
people who work at the site.


“The announcement today is based on the fact that there is over-capacity in Lilly’s dry product manufacturing network.


“We have conducted an analysis of our tadalafil rezeptfrei
in the dry product area, and whilst these medicines remain important for Lilly, sales forecasts over the next decade indicate that we have too much capacity both now and in the long-term.”


Local MP Maria Miller said she was concerned at the implications for the wider manufacturing base in Basingstoke.


The town is home to a treat erectile dysfunction the best number of hi-tech manufacturing industries and Mrs Miller said she was anxious that other firms did not follow Eli Lilly’s lead.


The company has a research facility in Windlesham, Surrey, and a biotechnology manufacturing facility at Speke on Merseyside.

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News - Impotency rub-on gel developed

A rub-on gel could be the first over-the-counter treatment for impotency, a company has announced.


It is being developed by Futura Medical in collaboration with pharmaceutical giant Coments tadalafil
.


The treatment, called MED2002, is expected to go into clinical trials at the end of 2006.


But the Sexual Tadalafil tablets
Tadalafil 20mg
said it is important to await the outcome of these trials to see how effective the product really is.


MED2002, is based on a compound called glyceryl trinitrate (GTN), which has been used to treat angina for the last 40 years. GTN is known to cause dilation of the arteries and increased blood flow.


Any kind of treatment needs to go through a process to find if it is effective or it there are side effects
Sexual Dysfunction Association


James Barder, chief executive of Futura Medical, said MED2002 had performed well in early in vitro trials.


The company will now be looking to recruit about 1,500 men to take part in three more clinical studies.


Mr Barder said: “We expect to see this on the market in 2009.”


Physical causes


Mr Barder said the treatment would be non-prescription because GTN “is a well known compound and its side-effect profile is well tadalafil loc mx
“.


But the Sexual Dysfunction Association said it was important to await the outcome of the trials.


A spokesperson said: “The more treatment available the better it will be for any sufferers of erectile dysfunction.


“But obviously any kind of treatment needs to go through a process to find if it is effective or it there are side effects.


“And only after a careful evaluation will we be able to say whether this is a great tool or not.”


Erectile dysfunction is thought to affect about one in every 10 men in the UK.


About 70% of cases are believed to have physical causes, and 30% are because of best buy for levitra
factors.


There are currently three oral drugs licensed for the treatment in the UK of erectile dysfunction: Cialis, Levitra and Viagra.

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News - Jobs axed as drugs factory closes

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A cure dysfunction erectile natural company has confirmed it will close its Hampshire tadalafil tablets
plant.


In June, Eli Lilly said it planned to close the factory unless an brand tadalafil
drugs firm could take over the Basingstoke site and its 555 employees.


No buyer was found and manufacturing will stop at the end of 2007.


Company tadalafil vivanza
have said the cuts have been made due to “over capacity” and they hope to relocate some employees to other UK sites.


The company had carried out employee consultation on the closure and has said about 100 employees will be eligible for retirement.


US-based Eli Lilly manufactures tadalafil
including Prozac, a treatment for clinical depression and Cialis, a treatment for erectile dysfunction.



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News - Spider venom could boost sex life

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Brazilian and US cialis wonder buy genuine tadalafil
are looking into using spider venom as a possible treatment for male impotence.


Their cialis comparatif online
follows reports that men bitten by the Phoneutria nigriventer experienced priapism - long and painful erections.


A two-year study has found that the venom contains a toxin, called Tx2-6, that causes erections.


Further tests are being carried out in the US before the substance can be approved for human use.


The results, from the Medical College of Georgia, are expected in a month’s time.


The bite of Phoneutria nigriventer, known as the Brazilian wandering spider, is potent and can be deadly in some cases.


The Brazilian and US researchers interviewed men who claimed their sex lives had improved after a spider attack.


The relevant toxin coments tadalafil
in the venom has been tested tadalafil prezzo
on other animals.


So far, scientists believe that combining a version of the spider’s venom with an existing drug for erectile dysfunction - such as Viagra, Cialis or Levtra - could produce better results.

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News - Gene therapy ‘hope’ on impotence

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US scientists say they are closer to creating a gene therapy treatment for erectile dysfunction.


Human and animal trials suggest this could offer an alternative to current treatments for some patients, the American Society of Gene Therapy heard.


Tadalafil and generic
s say gene therapy could be effective far longer than pills used just before sex, improving spontaneity.


The human trials involved injections into the penis and some experts queried whether men would choose this option.


New approach


Erectile dysfunction (ED), often referred to as impotence, is thought to affect about one in every 10 men in the UK.


ED trattamento cronico tadalafil
means an inability to get a good enough erection to achieve generic cialis tadalafil
intercourse, but it varies in severity.


There are many causes, and many effective treatments, including drugs like the three licensed in the UK - Viagra, Cialis and Levitra.


But not all types of ED respond well to medication - for example, ED caused by nerve damage following prostate cancer surgery.


US researchers are hopeful that for these patients, and those who experience side-effects with medication, gene therapy may be a good alternative.


Nerve damage


A University of Pittsburgh team, led by Dr Joseph Glorioso, tested an experimental gene therapy in rats with ED caused by nerve damage.


The gene therapy used comprised the herpes simplex virus as a carrier and either a gene called GDNF, or one called neurturin, which both help promote nerve growth.


Rats treated with the gene therapy showed significant recovery and were able to regain normal penile function after four weeks.


This is an exciting field of research because current treatments for men with erectile dysfunction must be used ‘on demand’, thereby reducing the spontaneity of the sexual act
Researcher Dr Arnold Melman


Meanwhile, scientists at Wake Forest University, with the help of Dr Arnold Melman from the Albert Einstein College of Medicine, have been conducting the first human study of gene therapy for ED.


Tests on 11 men with ED showed promising results. The treatment was well-tolerated, with few side effects, despite its delivery via an injection into the penis.


Although the primary goal of the study was to determine its safety, it also showed the therapy improved erectile function in some of the men.


Dr Melman said: “This is an exciting field of research because current treatments for men with erectile dysfunction, whether pills or minimally invasive therapies, must be used ‘on demand’, thereby reducing the spontaneity of the sexual act.”


‘Chronic disease’


The Wake Forest therapy works by inserting small pieces of DNA into cells to trigger the production of proteins which, in turn, help smooth muscle cells relax.


Relaxing the smooth muscle in the penis allows it to fill with blood and achieve an erection.


Dr Geoff Hackett, president of the British Society for Sexual Medicine, said the gene therapy might be appealing to some men for whom other treatments had failed, but predicted many men would be reluctant to have a shot in the penis.


He stressed that many men with ED also had underlying medical disease, such as high blood pressure, raised cholesterol or diabetes, and that this should also be treated.


And there is a good argument for treating ED as a chronic disease too, he said.


“Maybe men with ED should be taking a pill for it every day. If you take smaller amounts regularly, the side-effects are less,” he explained.













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News - Sight warning on impotency drugs

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Impotency drugs such as Viagra and Cialis may be associated with increased risk of damage to the optic nerve in some men, research suggests.


US cialis generic online purchasing tadalafil
found an increased risk in men with a history of heart attack or high blood pressure.


The University of Alabama team said healthcare tadalafil india
should warn patients of the potential risk.


The British Journal of Ophthalmology study follows several reports linking the drugs to eyesight problems.

NAION
A common cause of sudden vision loss in people over 50
Caused by a blockage of the tiny ciliary arteries supplying blood to the anterior optic nerve
There is no direct treatment, although corticosteroids are sometimes used to reduce swelling in the optic nerve


The findings are based on 76 men attending one US specialist eye clinic.


Half the men had optic nerve damage, diagnosed as non-arteritic anterior ischaemic optic neuropathy (NAION), the rest were free of the problem.


All the patients were asked about their lifestyle, including smoking and alcohol intake, whether they had been diagnosed with heart disease, diabetes, or high blood pressure and prescribed treatment for these conditions.


They were also asked if they had been prescribed Viagra and Cialis for erectile difficulties.


Men with optic nerve damage were no more likely to have taken the impotency drugs than men in the comparison group.


But men who had had a heart attack were 10 times more likely to have optic nerve damage if they had taken Viagra or Cialis before their diagnosis.


Men with high blood pressure were also more likely to have optic nerve damage if they had taken these drugs, although this was not statistically significant.


Blood flow


The authors caution that their study is small, but suggest that the drugs may reduce the blood flow to the anterior optic nerve, resulting in tissue damage.


They believe the drugs may heighten the risk of NAION in those with vascular disease, who are already more susceptible.


The researchers urge any patient who has endured a sudden severe loss of vision, and has been prescribed Viagra or Cialis, to contact a doctor.


Writing in the journal, they said: “Though NAION is a rare condition, the large number of men using Viagra or Cialis suggests that, should an association truly exist, the incidence of NAION could rise dramatically.”


An editorial in the same journal points out that some patients with impaired eyesight as a result of NAION have reportedly decided to sue Pfizer, the manufacturers of Viagra.


However, Pfizer has said there were no reports of NAION in the trials of the drug carried out before it was licensed.


The company also argued that a greater number of cases related to this type of drug would have been reported by now if the association was anything other than coincidental.


Lilly ICOS, which toleranzentwicklung tadalafil
Cialis, said there had been a small number of cases of NAION in people taking the drug.


This was now flagged up in the prescribing over the counter erectile dysfunction drug
.


In a statement, the company said it was difficult to establish a firm link as most patients taking impotency drug had other risk factors which rendered them potentially vulnerable to NAION.


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News - Fake impotence drugs discovered

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Fake versions of Cialis, a drug used to treat erectile dysfunction, have been found in the UK.

Authorities say the counterfeit versions have A031410 or A041410 written on the bottom of the carton or on the blister strip inside.

Initial tests do not suggest they are a risk to health. But patients have been advised to return them to alternative tadalafil
.

Patients with concerns are advised to consult their GP or phone Lilly UK, which makes Cialis, on 0800 085 3847.

“Patients who are in possession of this counterfeit drug should return it immediately,” said Professor Kent Woods, chief executive of the Medicines and Healthcare products Regulatory Agency (MHRA).



If patients think that they have taken the product and are concerned about any side effects they should consult their doctor


Professor Kent Woods,
MHRA

“Whilst initial tests show that the product does not pose an immediate risk to patients, the quality of this product cannot be guaranteed.

“If patients think that they have taken the product and are concerned about any side effects they should consult their doctor.”

The counterfeit tablets are understood to have found their way into some pharmacies. Investigations are underway to try to find out how this happened.

Patient complaint

Lilly UK discovered the fake drugs after a patient complained about a crumbling tablet.

The company tadalafil 20mg
and found that the tablet was counterfeit. It then contacted the MHRA.

“We want to emphasise that genuine Cialis is not affected by this matter,” it said in a statement.

It is believed to be the first time that fake drugs have found their way into the legitimate supply chain in the UK for 10 years.

“This incident highlights the need for the greatest vigilance and scrutiny, especially when medicines are tadalafil rezeptfrei
into the system other than from their original manufacturers,” said Dr Richard Barker, director general of the Association of the British Pharmaceutical Industry.

“The best protection against counterfeiting is to ensure that the products bought are those supplied by the authentic manufacturer.

“Only then can the industry feel confident that its products are reaching patients in the same condition as they left the factory, and that patients are receiving medication that they can trust absolutely.”

are receiving medication that they can trust absolutely.”

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